Dear sir or madam,[It's an advertised position with an application portal and all that. I didn't find any specific names for the committee, and since I'm technically applying for two positions at once it seemed like a bad idea to address the specific professor I'm aiming for.]
Good day! As an imminent graduate in biomedical science, please accept my interest in joining the [PROGRAMME] excellence cluster as a doctoral researcher.[Standard opening, but I wanted to inject a little friendliness so it sounds less robotic.]
This cluster sparked particular interest, as microbial interactions play a significant role in antibiotic resistance, my own primary interest. Though my own relationship with microbes does tend to be on the antagonistic side – it was the specific phrases ‘microbial communities in human hosts’, ‘infectious diseases on the microbiome level’, and ‘developing strategies for remediation by targeted interventions’ that seized my attention – my ecological and clinical backgrounds both emphasise the importance of environmental factors.[Did a BSc in ecology before being pivoted into medical research by lack of ecological work. Never actually got a job in that field, but I'm trying to leverage the degree into a bridge between my more medically-focussed experience and the microbiome focus of this research group.]
Soil bacteria, for example, have been identified as a reservoir for tetracycline destructases, and thus play a role in the proliferation of resistance to front-line drugs. And although my master’s thesis focussed on the killing of Pseudomonas aeruginosa when under stationary-phase conditions, the fact is that any in-vivo infection will be complicated by quorum-sensing and biofilm formation, expression of virulence-affecting regulators like RpoS, interspecific effects, and countless other factors. Medicine is becoming increasingly individualised, and supplanting the brute-force techniques of the past will require a more thorough comprehension of bacterial evolution.[This paragraph was an attempt to reference the cluster itself, and to justify how a focus on antibiotic resistance is applicable to them; their group deals with environmental microbes, the specific position will focus on a gram-negative pathogen grown under varying conditions, and the professor in question has previously published on RpoS. It's also supposed to show that I'm mentally flexible and don't have my head stuck up my arse, but I have no idea if it is actually a good idea to spend a paragraph essentially undermining the value of my own master's thesis.]
Apart from this, it would also be remiss to pretend that [CITY] itself holds no special appeal in its own right; the reputation for scientific renown and progressive philosophy, the cosy population density, and of course the nearby [NICE PLACE], together paint an enticing picture for any country Kiwi.[Look guys, I'm not just a beep-boop robot! And researched the wider area and stuff! I don't know. It's actually true, though, the location seems fucking amazing and is like half of why I'm so excited.]
Regarding my own background, this interest in combatting human pathogens reaches back into the mists of 2017; raised to become an engineer, I instead pursued an ecologically-focussed biology degree and then swerved into the realm of clinical trials. There I uncovered a buried passion, and by the expiration of my two-year working holiday visa, had served with distinction in three departments and gained a relative wealth of skills. But with only a bachelor’s I then found my further research opportunities sharply limited; the attempt to rectify this took me to [MASTER'S] and hopefully will lead next to [CITY] and the [INSTITUTE] University.[The details are in my CV, but I want to emphasise them, because I have no presence in academia, while my work history (although spread across the IT and biomedical sectors) is legit pretty impressive for my age. It's my best shot; can't afford for it to get overlooked.]
Although the fact is that my academic research experience does remain limited, life has taught me to embrace challenge; I am eager for the chance to further grow, to add to the biomedical corpus, and with luck to earn a place in the nation that has proven so remarkably welcoming. Between my academic, clinical, and technical backgrounds, today I am confident that I can rise to meet any occasion, and – should you have me – will prove a useful and dedicated addition to your team.[All completely true; the last ~6 years have been a fucking whirlwind and academia now seems thoroughly unintimidating. I also enjoy life here and am super enthusiastic about not getting deported. Unfortunately it all sounds painfully generic when written out...]
Please do not hesitate to contact me with any questions. Otherwise, I await your reply with hope and bated breath. Many thanks for your time, and for your consideration.
With best regards,
-[KP6]
Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. Proceedings of the National Academy of Sciences of the United States of America, 104 (47), 18490–18495. Gram-positive and Gram-negative bacteria use quorum sensing communication circuits to regulate a diverse array of physiological activities. These processes include symbiosis, virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation. In general, Gram-negative bacteria use acylated homoserine lactones as autoinducers, and Gram-positive bacteria use processed oligo-peptides to communicate. Recent advances in the field indicate that cell-cell Gram-positive bacteria Because peptides are impermeable to biological membranes, secretion of quorum- sensing peptides is usually mediated by specialized transporters Signaling is mediated by phosphorylation cascade that influences the activity of a DNA-binding transcriptional regulatory protein termed a response regulator. Gram-positive and Gram-negative bacteria use quorum sensing communication circuits to regulate a diverse array of physiological activities. These processes include symbiosis, virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation. Quorum Sensing in Gram-Negative Bacteria G lg n BOÞGELMEZ-TINAZ Department of Biology, Faculty of Art and Sciences, S leyman Demirel University, Isparta - TURKEY Received: 15.11.2002 Abstract:It has become increasingly and widely recognised that bacteria do not live as isolated entities but instead exist as communities that exploit elaborate systems of intercellular communication to Broadly, these can be split into two main categories: (1) amino acids and short peptides, commonly utilised by Gram-positive bacteria , , and (2) fatty acid derivatives, frequently utilised by Gram-negative bacteria. This review will summarise our current understanding of Gram-negative cell-to-cell signalling systems. Particular emphasis will be placed on the wide range of quorum-sensing Bacteria use quorum sensing to orchestrate gene expression programmes that underlie collective behaviours. Quorum sensing relies on the production, release, detection and group-level response to extracellular signalling molecules, which are called autoinducers. Recent work has discovered new autoinducers in Gram-negative bacteria, shown how these molecules are recognized by cognate receptors, revealed new regulatory components that are embedded in canonical signalling circuits and identified Broadly, these can be split into two main categories: (1) amino acids and short peptides, commonly utilised by Gram-positive bacteria and (2) fatty acid derivatives, frequently utilised by Gram-negative bacteria. This review will summarise our current understanding of Gram-negative cell-to-cell signalling systems. Particular emphasis will be placed on the wide range of quorum-sensing systems Quorum sensing pathways in Gram-positive and -negative bacteria: potential of their interruption in abating drug resistance. Haque S(1)(2), Yadav DK(3), Bisht SC(4), Yadav N(3), Singh V(5), Dubey KK(6), Jawed A(1), Wahid M(1), Dar SA(1)(7). Author information: (1)a Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University , Jazan , Saudi Arabia. (2)b (2019). Quorum sensing pathways in Gram-positive and -negative bacteria: potential of their interruption in abating drug resistance. Journal of Chemotherapy: Vol. 31, No. 4, pp. 161-187.
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This quorum sensing lecture under the quorum sensing video series demonstrates the fascinating mechanisms behind the bacterial chemical communication called ... Quorum sensing basic concept:https://youtu.be/ExY5yUn7mwUQuorum sensing in Gram Negative bacteria:https://youtu.be/f5mjfqoHTxolinks for other videos:Quorum Q... In this video we look at the process of quorum sensing, which is a mechanism of communication between bacterial cells. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators ... This quorum sensing in bacteria lecture under the quorum sensing tutorial series demonstrates the fascinating mechanisms behind the bacterial "chemical commu... A project for AP Biology. music: Easy Lemon- http://incompetech.com/ Explaining some examples which utilise Q.S for different purpose.Quorum sensing:https://youtu.be/ExY5yUn7mwUQuorum sensing in Gram positive bacteria:https://... Animated Video created using Animaker - https://www.animaker.com Quorum sensing is a communication process between bacteria, and allows bacteria to regulate ... Quorum sensing in Gram negative and Gram positive bacteria - Duration: 4:28. Shomu's Biology 28,346 views. 4:28 . Overview of cell signaling - Duration: 8:49. Khan Academy 388,360 views. 8:49. The ... This quorum sensing lecture explains the quorum sensing mechanism between Gram positive bacteria. It also illustrates the importance on intercellular signali...
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